Manduro returned to Royal Ascot and built on his placed effort of 12 months ago to capture the Prince Of Wales' Stakes for France's champion trainer Andre Fabre and rookie jockey Stephane Pasquier.
Christophe Soumillon was in the saddle last year when the five-year-old filled the third spot behind Ouija Board, but he had to sit and watch this time as his former partner soared home in emphatic fashion.
Pasquier settled the 15-8 favourite in third for much of the 10-furlong contest and asked him to settle matters with a potent turn of foot two furlongs out.
Market rival Dylan Thomas, ridden by Soumillon, tried to go with him but the Aidan O'Brien representative could not live with the Gallic challenger and finished a length-and-a-quarter adrift in second.
Fabre is always a man to instil fear into the hearts of his rivals with his ventures on British soil and Earl of Sefton Stakes winner Manduro was providing him with a sixth success at the Royal meeting.
Fabre said: "He was an aesthetic pleasure to watch and I didn't see a battle - there was just one horse.
"He got boxed in here last year and is a horse who needs space, so it was an interesting lesson.
"He hasn't really improved but we have got to know him better since last year. He needs a lot of space and to see daylight; then it is just a case of pressing the button."
Totesport were most impressed with Manduro and offer 6-1 about a Longchamp Arc victory, with VC Bet 8-1, William Hill and Boylesports 10s and Coral a standout 12-1.
Jimmy Fortune stole the honours with a glorious 339-1 treble on the second day of the Royal meeting.
The jockey showed his former back problems were well and truly behind him as he struck with brilliant victories on Tariq (15-2), Nannina (3-1) and Royal Oath (9-1).
The latter was blinkered for the first time and turned the Royal Hunt Cup, one of the most competitive handicaps of the season, into a procession, with Fortune bringing the John Gosden-trained colt home four lengths clear of the field.
Flipando was second, Vortex third and Supaseus fourth. "A treble at Royal Ascot is fantastic," said Fortune. "Royal Oath ran a very good race in the Spring Cup at Newbury. We thought he would win at Newmarket after that, but he was still a big baby.
"The boss put the blinkers on him and they made a difference. They went very quick and Supaseus was probably leading me two out, but he's run on like a Group horse."
Group races now beckon for Royal Oath as Gosden explained: "The plan had always been the Hunt Cup and we weren't going to waver from it. I put a little semi-blinker on him, just to make him concentrate, and he's showed his colours.
"His handicap days are over. We've got a plan to go to Keeneland in the autumn. We'll attack one of the Group races there over a mile."
Not many horses return to Royal Ascot to win different races in successive years but Nannina, Gosden and Fortune swept away with the Windsor Forest Stakes.
Twelve months ago she had captured the Coronation Stakes and was spot on for this Group Two event after a comeback third at Epsom. She did it in exquisite fashion, taking over from Wasseema with two furlongs to run.
Tariq earned himself a possible tilt at the Sussex Stakes at Goodwood with a classy victory in the Jersey Stakes, trouncing US Ranger by two-and-a-half lengths.
The Queen Mary Stakes went to Elletelle at 20-1, whose trainer Ger Lyons continues to reap the rewards of his decision to start sending raiders across the Irish Sea.
The two-year-old filly's dash looked set for a rare Sir Mark Prescott Royal Ascot winner as 4-1 favourite Starlit Sands hit the front, but she was worn down and held by half a length as Johnny Murtagh got a tune out of Elletelle.
Despite running incredibly green with an awkward head-carriage, Barshiba (16-1) got her act together to mow Selinka and Costume down inside the final half-furlong of the Sandringham Handicap. It was like old times, with Richard Quinn, recently out of retirement, teaming up with old friend David Elsworth.