PACY Harraby hitman Aaron Roberts left the Amble United defence in tatters as the leaders crashed to only their second defeat.
Roberts sent the goalkeeper the wrong way from the spot after Peter Ferris had been sent tumbling and was spot on again just after the hour when an Amble defender grabbed a fistful of shirt to pull him back.
He turned provider for the Cumbrians’ second as he squared for Dan Balmer to smash in from eight yards.
Although substitute Rikki Hume gave Amble a glimmer of hope when he drilled in with his first touch, it was quickly extinguished as Roberts was left free to drive home.
Lee Otway added to the Seasiders’ misery with the fifth as he danced around the goalkeeper and tucked away with nine minutes to go.
Wallsend Town’s Paul Gordon also celebrated a treble against Hebburn Reyrolle – then saw red.
Craig Burke marked his return with a double and Chris Garwood and Paul McHutcheon added the others, Rob Allen scoring twice in reply.
Goals from Paul Dunn, Dean Deagle and Chris Rue put Shankhouse in charge at Rutherford.
Shaun Todhunter pulled one back from the spot for Rutherford, but James Armstrong completed the scoring.
Whitley Bay A’s Daniel Chambers, Andrew Robertson and Kyle Downey hit the net in their win at Seaton Delaval, who had Alex Redfearn on target against his former team-mates.
Ashington Colliers were left stunned as they went out of the Kicks Leisure George Dobbins League Cup at Second Division Blyth Isabella, despite leading through a Kris Willis thunderbolt.
Kris Allington levelled and Matthew Lavender struck to put the underdogs into the semi-finals.
Wallington’s John Paxton scored as they surprised Carlisle City.