Newcastle Benfield Bay Plastics got off to a flyer when they hit Horden CW 4-1 at Welfare Park.
Ian Graham, Alu Bangura, Mark Atkinson and Richard Broadie struck before Horden claimed a consolation with a header from Stephen Thomas.
Morpeth Town were the biggest scorers when they put five past Tow Law Town, who replied three times.
Stephen Young completed a hat-trick but strikes by Scott Emmerson, Derek Waters and Lee Hamilton had the scores level with six minutes remaining. Morpeth retaliated to win 5-3 with efforts from Chris Philipson and Darren Grimes.
Newly-promoted Darlington RA lost 2-0 at Whitley Bay, for whom Darren Timmons and Mark Sheeran scored.
Consett celebrated their promotion with a 3-1 win at West Auckland Town, where they were three goals in front courtesy of Michael Mackay, Carl Piecha and Chris Renshaw. Danny Richmond was a late scorer for West.
An only goal by Anthony March was sufficient for Chester-le-Street at Sunderland Nissan and in another close game Billingham Synthonia shared the points with Durham City. Neil Campbell converted a penalty for the visitors before Lee Flanaghan levelled in the second half.
Jarrow Roofing were three goals up through Lee O'Donovan and Paul Chow (2) but when David Fox and Christopher Priest netted, West Allotment Celtic were in with a chance. Jarrow though held on.
Ashington scored three at Portland Park courtesy of Alan Hogg (2) and Glen Bolton but still lost to Billingham Town, whose scorers were Chris Emms (2), Stephen Huggins and Nathan Jamieson. Team Northumbria, promoted to the Second Division from the Northern Alliance, began with a 1-0 defeat at Crook Town, for whom Darren Harrison scored after two minutes.
Hebburn Town lost by a similar margin at another of the newcomers, Stokesley SC, who struck through Sonny Andrews with seven minutes to go.
North Shields were another side to lose by an only goal as Guisborough Town's Mark Ward volleyed in the winner on 81 minutes.
But goals rained in at Ryton where Sunderland Ryhope CA crashed to an 8-0 defeat. David McMahon (4), Craig Tate (3) and David Henderson struck.
Tony Healer capitalised on a defensive mistake to give Washington the lead at Spennymoor Town, who restored parity with a late goal from Mattie Peverell.
Alnwick and Prudhoe Town produced a good game, even though there were no goals, and South Shields clinched the points at the expense of Seaham Red Star with goals by Christopher Peacock and Simon Dolman after Nicky Martin had given the visitors the lead.