Newcastle Benfield Bay Plastics and Whitley Bay will be attempting to join the three Arngrove Northern League sides who reached the fourth round of the FA Carlsberg Vase last week when they play their delayed ties this afternoon.
Benfield host Castle Vale confident they can make progress against their visitors who are a level below them in the pyramid system. Should Benfield win they face the long trip to Truro.
Whitley Bay are also at home, against Coalville Town and they are boosted by the inclusion of Darren Timmons, Kevin Walton and Robbie Livermore.
Dunston Federation have found their scoring form in the last couple of matches which could be bad news for bottom side Bedlington Terriers.
The Fed, who have scored eight goals in their last two outings, have Kane Young free from suspension.
Leaders Sunderland Nissan visit Chester-le-Street hoping to avenge one of only three defeats they have suffered all season. They have signed Adam Clough, the former Middlesbrough player, from Spennymoor Town and Paul Stephenson also makes the squad but Gary Pearson is out.
Chester-le-Street have lost eight games at Chester Moor Park and they will give fitness tests to Paul Richardson and Robbie Draper. Gary Andison has completed a ban and junior Shaun Sagers could again be involved.
Consett manager Kenny Lindoe wants an immediate reaction from his players after last week's disappointing Vase result when they lost to Causeway United after being two goals up. The Steelmen meet West Auckland Town at Belle Vue Park.
Former Sunderland defender Dicky Ord has been confirmed as manager of Durham City until at least the end of the season. During his temporary time at the helm, City have racked up some excellent results and they are seventh from top ahead of their fixture with Billingham Synthonia at the Archibalds Stadium.
Ashington face a difficult challenge at second top Billingham Town where they will be minus leading scorer Alan Hogg with a knee injury while goalkeeper Aidan Ames is again absent from the West Allotment Celtic line-up at home to Jarrow Roofing.
In Division Two, Ryton will no doubt find it a lot more difficult at Sunderland RCA than they did on the opening day of the season when they thumped the Wearsiders 8-0.
Recent signings Lee Ludlow and Michael Fenwick are expected to return to the Ryton squad while RCA go into the game without Wayne Henderson, Scott Hembrough and Philip Hall.
Prudhoe Town line up against second from bottom Alnwick Town who have conceded more goals than any other side.
Scott Wilson and Gareth Edward are injured but a boost to the chances of Prudhoe is the return of goalkeeper Haythem Abbass.
Bruce Hogg is included in the Team Northumbria squad but Paul Dixon cannot play against Crook Town while Washington, fourth from top following some good results in recent weeks, go into their crucial fixture with leaders Spennymoor Town pleased to have Tom Faid back.